Generic Drug Interactions

Sildenafil Citrate

Mist trusted component Sildenafil Citrate comes within most notorious reactions when combined with nitrates or some of the similar products. If under any other of the consumption of medication including nitrates, ensure that you first consult the doctor before intake of the impotence treating solution. Chest or heart affected men are usually prescribed with the Nitrate based solution. Just for naming some of them to include nitroglycerin like Nitrostat, Nitro-Dur, Nitrolingual, Nitro-Bid, and others. Also, some of the isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), isosorbide mononitrate (Imdur, ISMO, Monoket), amyl nitrate or nitrite (poppers) are some of the other nitrate forms that could be a part of the ED medicine that are to be highly avoided for consuming in combination with ED solution. As, when nitrate is combined with the active component Sildenafil Citrate, it leads to some of the severe low blood pressure condition and shows up symptoms like dizziness, heart stroke, and fainting.


Strictly restrict intake of any of the organic nitrates while consumption of Tadalafil composed Erectile Dysfunction medicine. This particular combination results in life-threatening reactions like hypotension or extremely low blood pressure condition. Solutions that are composed of nitrate can only be taken after at least 48 hours of Tadalafil medicine consumption, which has to be consumed under complete doctor’s guidance. Other sex medicines like amyl nitrate, which is a form of organic nitrate that should be avoided within the same time.

Some below-listed chemical names and other medications that enhance the levels of Tadalafil content in the body, due to some of the reactions that are caused. This should be avoided by oral consumption that can be lowered in the levels of Tadalafil for overcome impotence issue.

  • Erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole, Ilosone)
  • Itraconazole (Sporanox)
  • Ketoconazole (Nizoral, Extina, Xolegel, Kuric)
  • Ritonavir (Norvir)
  • Indinavir (Crixivan)

Make sure that you consult your doctor if you are taking medicines that contain nitrate or any nitrate form like:

  • Isosorbide mononitrate (Imdur, Ismo, Monoket)
  • Isosorbide dinitrate (Isordil)
  • Nitroglycerin (Nitro-Dur, Transderm-Nitro)

Above listed chemicals (with the solutions in which these chemicals are found) are mainly prescribed for heart patients that are suffering from Angina or some of the other similar conditions. Undesirable reactions that are seen by coming together of Nitrates and Tadalafil are all the results in enhancement of the heart rate, which further leads to the cause of heart attack and a very low blood pressure.


Various drug interactions that are listed under this chemical component are usually general. It is difficult for always concluding the medicine when it is combined with consumption of some of the other solution. This occurs due to the difference in body types and yet some of the variables including some of them are listed below once:

  • Grapefruit or grapefruit juice is known for creating the bad reactions in men consuming Erectile Dysfunction medicines that are composed of Vardenafil component. This occurs due to the reaction is a cause for enhancement in the plasma concentrations of drug that are all substrates of the CYP450 3A4 iso-enzyme
  • Alcohol (Ethanol) consumed with Vardenafil risks is very low blood pressure level and also enhances hypotension, headache, dizziness and enhances the heart rate.
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